does Neurofascial Prolotherapy work?
Lyftogt found that a 5% dextrose solution injected subcutaneously
(versus at the fibro-osseous junction) could completely eliminate a
person’s pain immediately; though the treatment often has to be
repeated 5-8 times for complete pain resolution. The injections are
given just underneath the skin at the location of sensitized nerves.
These nerves are sensitized because of trauma or injury and represent
sites of neurogenic inflammation. Injections of 5% dextrose at these
sites can completely eliminate pain from neurogenic inflammation. Dr.
Lyftogt believes that these specific nerves are the ones that are
involved in the health and renewal of tissues such as ligaments,
tendons and cartilage. When the nerves regain their health, they can
again function to restore health to injured ligaments, tendons, and
are nociceptor peptidergic sensory nerves?
sensory nerves maintain the health of tissues such as ligaments and
tendons. When ligaments and tendons become degenerated, the
peptidergic sensory nerves are needed to “renew” them back to
health. Peptidergic sensory nerves thus are involved in the
health maintenance and renewal of joints and the soft tissue
structures around the joints. Without nerve support, tissues such as
ligaments and tendon degenerate. Dr. Lyftogt believes that injured or
inflamed peptidergic nerves lead to chronic pain (nociception) and
ultimately to degenerated ligaments, tendons and joints. They are not
the sole cause but a primary cause. To restore ligament, tendon and
joint health, the peptidergic sensory nerves have to be brought back
to health by subcutaneous Neurofascial Prolotherapy. The goal of both
Neurofascial Prolotherapy and Hackett-Hemwall Prolotherapy is the
same: elimination of pain through the restoration of ligament and
injures the peptidergic sensory nerves?
peptidergic nerves pierce the fascia to get to the subcutaneous
tissues including the ligaments, tendons and skin. As the
peptidergic nerves pierce the fascia they can become compressed and
the axonal flow in them restricted. Once the pressure in the
nerve (nervi neurvorum) rises above 30mmHg, axonal flow can stop.
It is often repetitive motions or repetitive strains that pinch
the peptidergic nerves as they exit the fascia. This neurogenic
inflammation then stops the nerves from providing health and renewal
to the tissues they support, thus ligaments and tendons can
degenerate. To regenerate these tissues, NFP is done to the
sites of nerve restriction and inflammation, ultimately causing the
nerves to heal, leading then to ligament and tendon health and
is chronic constriction injury?
peptidergic sensory nerves pierce the fascia when they go from their
deep location to just underneath the skin (subcutaneous). It is
at the points that they cross the fascia that they can become
chronically constricted. In this chronic constriction injury,
axonal flow can stop and the nerve suffers from neurogenic
inflammation. A 5% dextrose solution injected at areas of chronic
constriction injury not only relieves the inflammation but also
relieves the chronic constriction injury. This typically takes 5 to 10
weekly sessions, but can be curative.
inflammation neuritis a new term?
the above information on subcutaneous Neurofascial Prolotherapy and
neurogenic inflammation may all seem new, the concept of inflammation
on the nerve causing pain and even degeneration of tissues is an old
one. All one has to do is read Prolotherapy articles in the
1950s and 1960s from Dr. George Hackett, the person who coined the
term Prolotherapy, and he explains inflammation neuritis.4,5,6 So
it appears that he was the one that actually coined the term. He
noted that “inflammation neuritis and other antidromic impulses are
transmitted to blood vessels in nerves and surrounding tissues
stimulating a release of excess neurohumoral mediator substance which
cause a neurovascular vasdilation-edema-sterile inflammation
neuritis…This accounts for the pain and tenderness of inflamed
nerves we find in the arm with neuritis originating at the cervical
vertebra and in the thigh and leg with sciatic neuritis originating in
the 4, 5 lumbar vertebra and pelvis in sacroiliac-piriformis-sciatica.6 This
neurogenic inflammation can also lead to ligament weakness and bone
- Hackett GS. Ligament Uninhibited reversible antidromic
vasdilation in brochiogenic pathophysiologic disease. Lancet.
- Hackett GS. Ligament relaxation and osteoarthritis, loose
jointed versus close jointed. Rheumatism.
- Hackett GS, Huang TC, Raftery A. Prolotherapy for Headache. Pain
in the Head and Neck and Neuritis. Headache.
- Hackett GS, Huang TC. Prolotherapy for sciatica from weak pelvic
ligaments and bone dystrophy. Clinical
Medicine. 1961; 8:2301-2316.
- Hackett GS. Uninhibited reversible antidromic vasdilation in
pathophysiologic diseases: arteriosclerosis, carcinogenesis,
neuritis and osteoporosis. Angiology.